Are you at risk for cancer?

A cancer risk assessment can help identify if you or your family members are at an increased risk. This is important to help guide genetic testing, screening, therapy and management.

Could the cancers in you or your family be due to a hereditary cancer syndrome?

Did you know?

Transform your risks into action

With the support of our genetic experts gain insights into your personal risks for cancer based on your medical and family history,

Identify the suspected hereditary cancer syndrome.

Choose the most appropriate genetic test.

Discuss other cancers you might be at risk for.

Identify which family members are also at risk.

Learn about therapy and management options available based on your genetic test results.

When to consider a hereditary cancer syndrome?

Family members with the same cancer
Cancer onset in paired organs
Cancer onset in less common sex
Cancer onset in many generations
Cancer onset in many generations
Cancer onset in many generations
Cancer onset in many generations

Cancers and the genes associated with them

Learn more

Hereditary cancer syndromes only account for 10% of all cancers. However, recent studies have shown that they underdiagnosed and that all individuals with a diagnosis of cancer would benefit from genetic counselling and risk assessment.

Over 60 cancer syndromes caused by more than 100 different genes have been described to date. These syndromes can include cancers affecting all organs in the body including breast, uterine, prostate, kidney, thyroid, brain, colon, stomach and others.

Well-known cancer syndromes that can be inherited and confer increased risk of cancers

  • Hereditary breast and ovarian cancer syndrome:
  • Genes: BRCA1 or BRCA2.
  • Cancers: Breast, ovarian, pancreatic, prostate, melanoma
  • Women and men with BRCA1 or BRCA2 genetic mutations have a significantly higher risk of developing breast and other cancers than those without the mutations. Other cancers associated with the BRCA1 and BRCA2 genes include ovarian, pancreatic, prostate, and melanoma.
  • Mismatch repair genes that cause Lynch syndrome. This is a hereditary disorder caused by mutations in the mismatch repair genes MLH1, MSH2, MSH6, PMS2, and EPCAM. People born with mutations in these genes have a significantly higher risk of developing colon, endometrial, and other cancers such as stomach, pancreas, urinary tract, or brain.
  • CDH1. Mutations in the CDH1 gene are associated with hereditary diffuse gastric cancer, a rare type of stomach cancer, as well as breast cancer.
  • PALB2. Inherited mutations in the PALB2 gene are associated with an increased risk of breast cancer. Sometimes, this mutation can also be found in families with multiple cases of pancreatic cancer.
  • STK11. A mutation in the STK11 gene causes Peutz-Jeghers syndrome. People with this condition have a higher-than-average risk of developing cancers of the breast, cervix, ovary, gastrointestinal tract, and pancreas.
  • PTEN. Mutations in the PTEN gene have been linked to an increased risk of breast, head and neck squamous cell carcinoma, lung, and prostate cancers.

Frequently asked questions

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